THE royal quartet will narrate a short film launching the Every Mind Matters NHS campaign.
The three-minute video, will also feature the likes of Gillian Anderson and Davina McCall, and will be screened simultaneously.
What time is the Every Mind Matters advert with Meghan Markle Prince Harry, Prince William and Kate Middleton tonight?
The three-minute video will be screened at 8.45pm on tonight (Monday, October 7).
It will be introduced by presenter Clare Balding before being shown to an estimated 10.3 million UK viewers in what is believed to be a "broadcaster first".
What are the Royals role in the ad?
Narrating the video, William begins: "Everyone knows that feeling, when life gets on top of us.
"All over the country, millions of us face challenges to our mental health – at all ages – at all intensities, and for all sorts of reasons.
"We feel stressed, low, anxious, or have trouble sleeping. Me, you…"
Harry continues: "…your brother, your mother, your colleague, or your neighbour. Waiting, wondering, hoping, hurting.
"We think there's nothing to be done. Nothing we can do about it."
Meghan then counters: "But that's so wrong. There are things we can do. From today, there's a new way to help turn things around. Every Mind Matters will show you simple ways to look after your mental health."
Kate continues: "It'll get you started with a free online plan designed to help you deal with stress, boost your mood, improve your sleep and feel more in control."
Which channels is it on?
It will broadcast during ad breaks on Sky, Channel 4, ITV, Channel 5 and MTV.
But as well as being aired on the main channels the website also points users to existing apps which can help them keep track of good habits to protect their wellbeing.
It comes as a new PHE survey of more than 3,000 adults in England found that 83% of respondents had experienced early signs of poor mental health in the last year including feeling anxious, stressed, having low mood or trouble sleeping
Over a quarter of these waited longer than six months before taking action, with more than half reporting coping mechanisms including smoking, drinking or unhealthy eating and avoiding social situations.
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